Long Noncoding RNAs Usher In a New Era in the Biology of Enhancers
نویسندگان
چکیده
Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.
منابع مشابه
Enhancer RNAs: a class of long noncoding RNAs synthesized at enhancers.
Recent studies have revealed that active enhancers are transcribed, producing a class of noncoding RNAs called enhancer RNAs (eRNAs). eRNAs are distinct from long noncoding RNAs (lncRNAs), but these two species of noncoding RNAs may share a similar role in the activation of mRNA transcription. Emerging studies, showing that eRNAs function in controlling mRNA transcription, challenge the idea th...
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ورودعنوان ژورنال:
- Cell
دوره 154 شماره
صفحات -
تاریخ انتشار 2013